Follow us on

Our blog

Jul 05, 2021

Micro-fragmented adipose tissue (Lipogems) for patients with degenerative arthritis and degenerative meniscal tears

A recent publication by Dr. Gerard Malanga from New Jersey Regenerative Institute recently published a pilot study looking at micro-fragmented adipose tissue as a potential treatment for patients with knee pain secondary to osteoarthritis and meniscal tears.

In this study, there were 20 patients. At 1-year after the procedure there was a significant improvement in pain and function in patients treated with micro-fragmented adipose tissue using the Lipogems system. There were no serious adverse events in this study. One patient had local swelling at the harvest site and was treated with antibiotics, and other complications were minor and mostly limited to the adipose harvest.

The authors concluded that “micro-fragmented adipose tissue injected directly into a torn meniscus and knee joint using ultrasound guidance represents a safe and potentially efficacious treatment option for patients with knee pain suffering from degenerative arthritis and degenerative meniscal tears” (Malanga et al 2021).

What is a degenerative meniscus tear and how are these tears traditionally treated?

Meniscus tears are a common injury in the knee. Degenerative meniscus tears are commonly associated with osteoarthritis in patients over the age of 40. Typically, management initially starts with conservative treatments, including physical therapy, pain medications and injections. Surgery is often recommended if conservative treatment fails.

However, surgery for degenerative meniscus tears remains controversial and the management has shifted to preservation and repair of the meniscus. An expert panel made a strong recommendation against arthroscopic surgery for degenerative knee disease based on a review of current studies. They found that among patients with degenerative medial meniscus tears that results of knee arthroscopy was no better than exercise therapy (Siemienjuk et al. 2017).

There remains a lack of nonsurgical treatments for patients who have failed conservative management.

What are orthobiologic treatments?

Orthobiologic treatments include platelet rich plasma (PRP) injections and mesenchymal stromal cell (MSC) based therapies. MSCs can be harvested form bone marrow concentrate or adipose tissue. MSCs act as trophic mediators and secrete a variety of growth factors and cytokines that stimulate tissue intrinsic reparative or stem cells to heal tissue (Caplan & Dennis, 2006).

What is micro-fragmented adipose tissue?

Micro-fragmented adipose tissue, or MFAT, is one method of harvesting mesenchymal stromal cells or stem cells (MSCs). This process uses the patient’s own fat cells (autologous use), and the cells are processed without the use of enzymes or additives to concentrate the adipose-derived mesenchymal stem cells. The adipose graft can serve as a tissue filler in defects such as a torn meniscus and cartilage lesion, and the mesenchymal stem cells within the graft are thought to enhance the natural healing potential of the adipose graft. (Striano et al. 2017).

In Malanga et al.’s article the MFAT graft was processed using the Lipogems processing kit.

How is a micro-fragmented adipose tissue or Lipogems procedure performed?

The procedure starts with the patient lying on their belly on the procedure table. The region where the fat will be harvested is identified. This is generally the fat in the abdomen around the belly button or the “love handle” area. The fat is then injected with numbing medication using sterile technique (tumescent combining lidocaine and epinephrine and sterile saline).

After then area is numb the fat is harvested. Once the fat is removed it is processed using the Lipogems kit to remove blood/oil and fragment the fat. The fat is then concentrated into an adipose tissue graft, before being injected into the meniscus tear and knee joint using ultrasound guidance.

One important aspect of this procedure is the use of direct ultrasound visualization of the meniscal tears and lipofilling of these meniscal defects rather than just performing and intra-articular injection.

How limited are you after a micro-fragmented adipose tissue procedure for a meniscus tear?

After the procedure patients are placed in an unloader brace and will use crutches for one week. After the first week, patients can return to normal daily activity. Patients will continue to avoid bending the knee past 90 degrees. At 4-weeks post-procedure patients can return to running and jumping activities, and can return to full activity at 6 to 8-weeks.


Lipogems or micro-fragmented adipose tissue (MFAT) is one method of harvesting mesenchymal stromal cells or stem cells (MSCs). Learn more about how Lipogems is performed here.

Meniscal Tears

Meniscal tears are common and the trend is to offer treatments that preserve the meniscus. Learn more about alternatives to surgery.

FDA Guidelines on Orthobiologics

Learn more about FDA guidelines that regulate orthobiologics and consumer protections. Ensure your stem cell procedure is safe and complies with existing FDA guidelines

To learn more about alternatives to surgery for degenerative meniscus tear contact us for a consultation:

(781) 591-7855
20 Walnut St.
Suite 14
Wellesley MA


  1. Caplan AI, Dennis JE (2006) Mesenchymal stem cells as trophic mediators. J Cell Biochem 98:1076–1084.
  2. Malanga GA, Chirichella PS, Hogaboom NS, Capella T. Clinical evaluation of micro-fragmented adipose tissue as a treatment option for patients with meniscus tears with osteoarthritis: a prospective pilot study. Int Orthop. 2021 Feb;45(2):473-480.
  3. Siemieniuk RAC, Harris IA, Agoritsas T, Poolman RW, Brignardello-Petersen R, Van de Velde S, Buchbinder R, Englund M, Lytvyn L, Quinlan C, Helsingen L, Knutsen G, Olsen NR, Macdonald H, Hailey L, Wilson HM, Lydiatt A, Kristiansen A (2017) Arthroscopic surgery for degenerative knee arthritis and meniscal tears: a clinical practice guideline. BMJ 357:j1982.
  4. Striano RD, Battista V, Bilboo N (2017) Non-responding knee pain with osteoarthritis, meniscus and ligament tears treated with ultrasound guided autologous, micro-fragmented and minimally manipulated adipose tissue. Open J Regen Med 6:17–26.

More Articles

Feb 13, 2024

Tenex versus PRP for Tennis Elbow: Which minimally invasive treatment is superior ?

A recent study showed that the Tenex procedure was successful in 87.7% of the patients with tennis elbow and PRP effective in 84.6% of patients. In patients with tennis elbow (lateral epicondylitis) that have not

Read More
Feb 12, 2024

Is Tenex effective for Tennis elbow? What is the role of rehabilitation?

A tenotomy under ultrasound guidance using the Tenex device has been shown to be a viable and effective procedure for patients with tennis elbow regardless of the severity of the tendon pathology. This study found that

Read More