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Ulnar Neuritis

What is Ulnar Neuritis?

  • The ulnar nerve is one of the three main nerves in the arm and can become entrapped at several places along the course.

  • Ulnar neuritis, also known as ulnar neuropathy or cubital tunnel syndrome, is a condition characterized by compression or irritation of the ulnar nerve, and the most common site of entrapment is at the elbow. This condition is the second most common entrapment neuropathy of the upper extremity after carpal tunnel syndrome [Mondelli et al 2005; Caliandro et al 2012; Elhassan & Steinmann, 2007; Cambon-Binder, 2021; Carter et al, 2016].

What are common causes of ulnar nerve inflammation (ulnar neuritis)?

  • Common causes of ulnar neuritis include:
    • Compression at the elbow: This is the most frequent cause, often occurring at the cubital tunnel. Compression can be static, due to anatomical structures like the cubital tunnel retinaculum and Osborne's ligament, or dynamic, due to nerve instability such as subluxation or dislocation [Cambon-Binder, 2021; Posner, 1998; Omejec & Podnar, 2016].
    • Trauma: Acute or repetitive trauma to the elbow or forearm can lead to ulnar nerve inflammation [Felice & Royden Jones, 1996].
    • Occupational factors: Repetitive activities or prolonged elbow flexion, often seen in manual laborers, can contribute to ulnar nerve compression and subsequent inflammation [Mezian et al, 2021; Omejec & Podnar, 2016].
    • Anatomical variations: Variations such as the presence of accessory muscles (e.g., anconeus epitrochlearis), fibrous bands, or osteophytes can predispose individuals to ulnar nerve compression. Space-occupying lesions, including tumors, ganglions, or other masses can compress the ulnar nerve at various points along its course [Campbell et al, 1991; Wegiel et al, 2022; Earp et al, 2014].
    • Systemic conditions: Metabolic disorders, such as diabetes, and inflammatory conditions can also contribute to ulnar nerve inflammation by causing nerve entrapment or direct nerve damage [Andreisek et al, 2006; Earp et al, 2014].

What are the symptoms of ulnar neuritis?

  • Ulnar nerve inflammation, also known as ulnar neuropathy, typically presents with a range of symptoms that reflect the nerve's sensory and motor functions. Common symptoms include numbness and tingling in the hand and fingers, and patient can have the sensation that the little finger and ring
    fingers are falling asleep.

  • The primary symptoms include:

    • Sensory disturbances: Patients often experience numbness, tingling, or dysesthesias in the fourth and fifth digits (ring and little fingers). This can extend to the ulnar side of the hand and forearm [Elhassan & Steinmann, 2007; Carter et al, 2016; Yalcin et al, 2015].

    • Motor deficits: There may be weakness in the intrinsic muscles of the hand, particularly those innervated by the ulnar nerve, such as the abductor digiti minimi and the first dorsal interossei muscles. This can lead to a reduced grip strength and difficulty with fine motor tasks [Elhassan & Steinmann, 2007; Yalcin et al, 2015; Huang et al, 2004].

    • Pain: Pain is commonly reported along the ulnar aspect of the forearm and elbow, often exacerbated by elbow flexion or pressure on the cubital tunnel [Carter et al, 2016; Clark, 1979].

    • Muscle atrophy: In chronic cases, there may be visible atrophy of the hypothenar eminence and the interosseous muscles of the hand [Huang et al, 2004; Clark, 1979].

What are the treatment options for ulnar neuritis?

NON-SURGICAL TREATMENTS

  • The outcomes and success rates of various treatment options for ulnar neuritis vary depending on the severity of the condition and the specific treatment modality used. In most cases, symptoms of ulnar neuritis can be managed without surgery.

    • Activity modification and splinting: Rigid night splinting combined with activity modification has shown high success rates, with 88% of patients avoiding surgery and significant improvements in symptoms and functional scores [Shah et al, 2013]. Patients should avoid activities that exacerbate symptoms, including:

      • Avoiding activities that require you to bend the arm for prolonged periods of time.

      • Avoid leaning on the elbow.

      • Keeping the elbow straight when you are sleeping. This can be done with a brace that keeps the elbow straight.

    • Injections:

      • Corticosteroid injections: Corticosteroid injections have been studied for their ability to reduce inflammation and alleviate symptoms. However, their effectiveness compared to placebo has been mixed. One study found no significant difference in symptom improvement between corticosteroid and placebo injections, with a success rate of 30% in the corticosteroid group versus 28% in the placebo group. Another study indicated that corticosteroid injections combined with splinting did not provide additional benefit over splinting alone [Hong et al, 1996; vanVeen et al, 2015]. Potential side effects of corticosteroid injections include local tissue atrophy and depigmentation [Alblas et al, 2012; Buntragulpoontawee et al, 2021].
      • Prolotherapy: Dextrose injections have shown promising results. A randomized controlled trial demonstrated that perineural dextrose injections were effective in reducing symptom severity and the cross-sectional area of the ulnar nerve, with improvements noted from the third month onward. Dextrose injections were found to be more effective than corticosteroids in some studies [Chen et al, 2020; Buntragulpoontawee et al, 2021].
      • Platelet-rich plasma (PRP) injections:• PRP injections have also shown favorable outcomes in treating peripheral nerve entrapments, including ulnar neuropathy. PRP has been associated with significant improvements in pain and functional scores. PRP injections are generally safe, with no serious adverse events reported [Buntragulpoontawee et al, 2021].
    • Hydrodissection for ulnar neuritis has shown promising outcomes, particularly when compared to other non-surgical and surgical treatment options. Hydrodissection involves the injection of fluid around the ulnar nerve to separate it from surrounding tissues, reducing compression and inflammation.
      • A systematic review found that ultrasound-guided hydrodissection using injectates such as normal saline, 5% dextrose in water (D5W), corticosteroids, and platelet-rich plasma (PRP) is effective in reducing pain and improving nerve function. Both D5W and PRP showed consistently favorable outcomes compared to control groups or corticosteroids, with significant improvements in pain intensity, clinical symptoms, and nerve cross-sectional areas. No serious adverse events were reported [Buntragulpoontawee et al, 2021].
      • Learn more about hydrodissection procedures here.

SURGICAL

  • Non-surgical treatments are effective for mild to moderate cases and can help avoid surgery, but in severe cases or when non-surgical treatments fail surgical treatments have a high success rates

    • Factors such as hand numbness, ulnar nerve subluxation, and concomitant ulnar collateral ligament injury are associated with poorer outcomes with non-surgical treatments and may require surgery [Maruyama et al, 2017].
    • Pronounced nerve thickening and the presence of motor conduction block on EMG are associated with poorer outcomes with non-surgical treatments and may require surgery [Beekman et al, 2004].
  • Surgical treatments include:
    • In-situ decompression: This is often the first-line surgical treatment for stable ulnar nerve compression at the elbow [Shah et al, 2013; Pompe et al, 2020].
    • Anterior transposition: For cases where the nerve is unstable, anterior subcutaneous transposition is recommended. Anterior submuscular transposition is generally not recommended due to higher complication rates [Celik et al, 2024].


RESOURCES

  • Abuzinadah AR, Addas BMJ. Ulnar Neuropathy at the Elbow Associated With Focal Demyelination in the Proximal Forearm and Intraoperative Imaging Correlation. Front Neurol. 2019 Mar 27;10:292.
  • Alblas CL, van Kasteel V, Jellema K. Injection with corticosteroids (ultrasound guided) in patients with an ulnar neuropathy at the elbow, feasibility study. Eur J Neurol. 2012 Dec;19(12):1582-4.
  • Andreisek G, Crook DW, Burg D, Marincek B, Weishaupt D. Peripheral neuropathies of the median, radial, and ulnar nerves: MR imaging features. Radiographics. 2006 Sep Oct;26(5):1267-87.
  • Beekman R, Wokke JH, Schoemaker MC, Lee ML, Visser LH. Ulnar neuropathy at the elbow: follow-up and prognostic factors determining outcome. Neurology. 2004 Nov 9;63(9):1675-80.
  • Buntragulpoontawee M, Chang KV, Vitoonpong T, Pornjaksawan S, Kitisak K, Saokaew S, Kanchanasurakit S. The Effectiveness and Safety of Commonly Used Injectates for Ultrasound-Guided Hydrodissection Treatment of Peripheral Nerve Entrapment Syndromes: A Systematic Review. Front Pharmacol. 2021 Mar 5;11:621150.
  • Caliandro P, La Torre G, Padua R, Giannini F, Padua L. Treatment for ulnar neuropathy at the elbow. Cochrane Database Syst Rev. 2016 Nov 15;11(11):CD006839.
  • Cambon-Binder A. Ulnar neuropathy at the elbow. Orthop Traumatol Surg Res. 2021 Feb;107(1S):102754.
  • Campbell WW, Pridgeon RM, Riaz G, Astruc J, Sahni KS. Variations in anatomy of the ulnar nerve at the cubital tunnel: pitfalls in the diagnosis of ulnar neuropathy at the elbow. Muscle Nerve. 1991 Aug;14(8):733-8.
  • Carter GT, Weiss MD, Friedman AS, Allan CH, Robinson L. Diagnosis and Treatment of Work-Related Ulnar Neuropathy at the Elbow. Phys Med Rehabil Clin N Am. 2015 Aug;26(3):513-22.
  • Çelik G, Doğan ŞK, Filiz MB. Evaluation of the efficacy of low-level laser therapy in the treatment of ulnar neuropathy at the elbow in terms of symptoms and clinical and electrophysiological findings: a randomized, prospective, double-blind clinical trial. Lasers Med Sci. 2024 Sep 27;39(1):243.
  • Chen LC, Ho TY, Shen YP, Su YC, Li TY, Tsai CK, Wu YT. Perineural Dextrose and Corticosteroid Injections for Ulnar Neuropathy at the Elbow: A Randomized Double-blind Trial. Arch Phys Med Rehabil. 2020 Aug;101(8):1296-1303.
  • Clark CB. Cubital tunnel syndrome. JAMA. 1979 Feb 23;241(8):801-2.
  • Earp BE, Floyd WE, Louie D, Koris M, Protomastro P. Ulnar nerve entrapment at the wrist. J Am Acad Orthop Surg. 2014 Nov;22(11):699-706.
  • Elhassan B, Steinmann SP. Entrapment neuropathy of the ulnar nerve. J Am Acad Orthop Surg. 2007 Nov;15(11):672-81.
  • Felice KJ, Royden Jones H Jr. Pediatric ulnar mononeuropathy: report of 21 electromyography documented cases and review of the literature. J Child Neurol. 1996 Mar;11(2):116-20.
  • Hong CZ, Long HA, Kanakamedala RV, Chang YM, Yates L. Splinting and local steroid injection for the treatment of ulnar neuropathy at the elbow: clinical and electrophysiological evaluation. Arch Phys Med Rehabil. 1996 Jun;77(6):573-7.
  • Huang JH, Samadani U, Zager EL. Ulnar nerve entrapment neuropathy at the elbow: simple decompression. Neurosurgery. 2004 Nov;55(5):1150-3.
  • Maruyama M, Satake H, Takahara M, Harada M, Uno T, Mura N, Takagi M. Treatment for Ulnar Neuritis Around the Elbow in Adolescent Baseball Players: Factors Associated With Poor Outcome. Am J Sports Med. 2017 Mar;45(4):803-809.
  • Mezian K, Jačisko J, Kaiser R, Machač S, Steyerová P, Sobotová K, Angerová Y, Naňka O. Ulnar Neuropathy at the Elbow: From Ultrasound Scanning to Treatment. Front Neurol. 2021 May 14;12:661441.
  • Mondelli M, Giannini F, Ballerini M, Ginanneschi F, Martorelli E. Incidence of ulnar neuropathy at the elbow in the province of Siena (Italy). J Neurol Sci. 2005 Jul 15;234(1-2):5-10. doi: 10.1016/j.jns.2005.02.010. Epub 2005 Apr 20. PMID: 15993135.
  • Omejec G, Podnar S. What causes ulnar neuropathy at the elbow? Clin Neurophysiol. 2016 Jan;127(1):919-924.
  • Pompe SM, Schreuder T, Teunissen LL, Visser LH, Beekman R. In situ decompression vs conservative treatment for mild ulnar neuropathy at the elbow. Muscle Nerve. 2020 Aug;62(2):247-253.
  • Posner MA. Compressive ulnar neuropathies at the elbow: I. Etiology and diagnosis. J Am Acad Orthop Surg. 1998 Sep-Oct;6(5):282-8.
  • Shah CM, Calfee RP, Gelberman RH, Goldfarb CA. Outcomes of rigid night splinting and activity modification in the treatment of cubital tunnel syndrome. J Hand Surg Am. 2013 Jun;38(6):1125-1130.e1.
  • vanVeen KE, Alblas KC, Alons IM, Kerklaan JP, Siegersma MC, Wesstein M, Visser LH, Vankasteel V, Jellema K. Corticosteroid injection in patients with ulnar neuropathy at the elbow: A randomized, double-blind, placebo-controlled trial. Muscle Nerve. 2015 Sep;52(3):380-5.
  • Węgiel A, Zielinska N, Tubbs RS, Olewnik Ł. Possible points of compression of the ulnar nerve: Tricks and traps that await clinicians from an anatomical point of view. Clin Anat. 2022 Mar;35(2):155-173.